Likewise, aberrant increases of APC10 and APC11 proteins, which are two subunits of the APC/C encoded by ANAPC10 and ANAPC11 genes, have been recently evidenced in non-small cell lung and colorectal cancer tissues (77, 78); interestingly, inhibitors of APC/C activity are currently under investigation (67). Here, APC is linked to colorectal cancer.