For instance, estradiol could modulate RIZ2/RIZ1 ratio also through various miRNAs that control estradiol response in breast cancer cells (43); interestingly, some of these target consensus sequences could be recognized in the exon 9 of PRDM2 gene by bioinformatics analysis (http://mirdb.org/cgi-bin/search.cgi). This evidence concerns the gene PRDM2 and breast carcinoma.