SULF1 and neoplasm: The fold-change of SULF1 and SULF2 upregulation in tumor among these 43 patients are moderately correlated (Pearson’s r = 0.563, p < 0.001, Figure 1B), as is the mRNA expression in tumor tissues in all 499 patients (r = 0.390, p < 0.001, Supplementary Figure 1A).