SIRT4 and pancreatic ductal adenocarcinoma: Recently, it has been shown that in pancreatic ductal adenocarcinoma (PDAC), SIRT4 could deacetylate branched-chain amino acid transaminase 2 (BCAT2) at lysine 44 (K44), and that BCAT2 was stabilized by SIRT4 deacetylation, which promoted catabolism of branched-chain amino acids, cell proliferation and the growth of pancreatic tumors (34).