Further investigations about cancer cell cytoskeleton and their response to mechanical stimuli namely – pressure and shear forces (as it clinically happens during manipulations, manual or instrumental massage) showed that their integrin-binding affinity and intrinsic adhesion signaling system can be modified, the biological impact of the physical energies upon the natural history of cancer is currently deeply investigated, high pressure long time exposure promotes cancer cell multiplication through a cytoskeleton-dependent signaling mechanism requiring FAK, Src, Akt, and paxillin (Figure 8). The gene discussed is PXN; the disease is cancer.