Model II was further adjusted for TPOAb, TgAb, Tg, and BMI), the correlation still remained that the absence of hypercholesterolemia could reduce the risk of thyroid nodules being malignant [Model I: OR = −0.54, 95% CI (−0.87, −0.21), P = 0.001; Model II: OR = −0.75, 95% CI (−1.39, −0.12), P = 0.02]. The gene discussed is TG; the disease is familial hypercholesterolemia.