So far, 10 members (TLR1-TLR10) have been identified in TLR family which involved in multiple biological processes, such as inflammatory response, immune response, apoptosis and angiogenesis and further contributed to the development of various cancers (Belmont et al., 2014; Dajon, Iribarren & Cremer, 2017; Garcia et al., 2016; Paone et al., 2010; Vijay, 2018). Here, TLR1 is linked to cancer.