Notable examples associated with aggressive cancer and adverse outcomes include HOTAIR (HOX transcript antisense RNA), which is upregulated in a range of cancers (Huarte, 2015), and the prostate cancer-specific SCHLAP1 (SWI/SNF Complex Antagonist Associated With Prostate Cancer 1) (Prensner et al., 2013). Here, HOTAIR is linked to Familial prostate cancer.