Loss of PPP2R2C expression has been attributed to esophageal adenocarcinoma tumorigenesis (Peng et al., 2017), and PPP2R2C downregulation by distinct microRNAs positively correlates with increased proliferation of cultured cancer cells derived from the prostate (Bi et al., 2016), nasopharynx (Yan et al., 2017), and ovary (Wu et al., 2016). The gene discussed is PPP2R2C; the disease is cancer.