Figure 1 shows differently expressed spots in patients and healthy controls. Two spots in proteins showed an over-expression in cirrhotic sera, whereas 5 proteins showed a lower expression. The expression of Ig alpha -1 chain C region, Ig kappa chain C region, alpha 1-B glycoprotein and complement 3 and one of the spots of haptoglobin was significantly higher in advanced HCV-cirrhotic septa. Additionally, 1 spot of haptoglobin and apo lipoprotein 4 show lower lever of expression in advanced HCV- cirrhosis (Supporting Table 2). Here, HP is linked to Cirrhosis.