Our analysis showed that deregulation of ALB, IL6, INS, CXCL8, TNF, PTGS2, EGFR, VEGFA, IL4, TP53, and ADIPOQ is a major event in GERD which is associated with alteration in the several terms clustered as “IL17 signaling pathway”. This evidence concerns the gene PTGS2 and gastroesophageal reflux disease.