They concluded that SOAT1 is critical for maintaining cholesterol level to localize the trans-membrane receptors of HCC cells to growth and metastasis.Other researches in cholesterol maintenance revealed that loss of tumor suppressor factor p53 activates master transcription regulator of cholesterol synthesis pathway, and promotes maturation of sterol regulatory element binding protein 2 (SREBP2) for HCC development (68). The gene discussed is TP53; the disease is hepatocellular carcinoma.