Previously, Xu et al. (2015) reported that genetic disruption of Ano5 in mice did not lead to the development of muscular dystrophy, in contrast to the reports that mutations in ANO5 are responsible for limb girdle muscular dystrophy type 2L (LGMD2L) or Miyoshi myopathy type 3 (MMD3) in patients (Bolduc et al., 2010; Hicks et al., 2011; Magri et al., 2012; Pénisson-Besnier et al., 2012; Schessl et al., 2012; Little et al., 2013; Witting et al., 2013). The gene discussed is ANO5; the disease is muscular dystrophy.