Five other complex conditions [ASD (O’Roak et al., 2012), bipolar disorder (Ross et al., 2016), developmental delays (Di Gregorio et al., 2017), and hearing impairment and intellectual disability (Garza-Lopez et al., 2018)] have been associated with Cav1.3 variants, but the exact causality remains unclear. Here, CACNA1D is linked to Global developmental delay.