Knockdown of PRPF6 expression in human cancer cell lines with increased levels of PRPF6 inhibited cell growth in vitro, and inducible knockdown of PRPF6 in xenograft tumours led to tumour shrinkage only in tumour models with high PRPF6 expression (Adler et al., 2014). Here, PRPF6 is linked to neoplasm.