PRPF31 and retinitis pigmentosa 1: Interestingly, in retinal organoids derived from PRPF31-defective RP patients, there was an enrichment for differentially expressed genes related to the ciliary membrane and the primary cilium, while fibroblasts from the same PRPF31 RP patients had significant mis-splicing of genes involved in ciliogenesis (Buskin et al., 2018).