For example, in PTEN-deficient prostate cancer, lncRNA PCAT1 directly binds to FKBP51 and replaces PHLPP in the PHLPP/FKBP51/IKKα complex, thereby activating AKT and NF-κB signals and accelerating the progression of the disease (Shang et al., 2019). Here, NFKB1 is linked to Familial prostate cancer.