For example, in PTEN-deficient prostate cancer, lncRNA PCAT1 directly binds to FKBP51 and replaces PHLPP in the PHLPP/FKBP51/IKKα complex, thereby activating AKT and NF-κB signals and accelerating the progression of the disease (Shang et al., 2019). The gene discussed is NFKB1; the disease is prostate carcinoma.