GSVA analysis showed that HEME _ METABOLISM, TGF_BETA_SIGNALING, KRAS_SIGN ALING_UP, IL6_JAK_STAT3_ SIGNALING, INFLAMMA TORY_RESPONSE were activated in BC patients from the high-risk group, and ESTROGEN_RESPONSE_LATE, MYC_TARGETS_V1, DNA_REPAIR, and INTERFE RON_GAMMA_RESPONSE were inhibited (Supplementary Figure 2B and Supplementary Table 6). The gene discussed is IL6; the disease is breast cancer.