The dysregulation of RAB3A and RAB27A has already been linked to Alzheimer’s and other neurodegenerative disorders (Davidsson et al., 2001; Ginsberg et al., 2011; Bereczki et al., 2016; Iguchi et al., 2016), while the ancestral RPH3A (Rabphilin 3A) gene (Craxton, 2010) was found to influence dementia severity, cholinergic deafferentation, and increased β-amyloid concentrations in postmortem neocortex of Alzheimer’s disease patients (Tan et al., 2014). Here, RPH3A is linked to Alzheimer disease.