Unlike in RA, ENO1 autoantibodies from CAR patients do not specifically target citrullinated peptides but rather recognize several epitopes, including an immunodominant N-terminal domain peptide, 56RYMGKGVS63, and a C-terminal peptide implicated in plasminogen binding, 421AKFAGRNF428 (Adamus et al., 1998). This evidence concerns the gene ENO1 and rheumatoid arthritis.