These functions can be inhibited in cancer cells by ENO1 depletion (Georges et al., 2011; Song et al., 2014; Fu et al., 2015; Zhu et al., 2015; Capello et al., 2016; Principe et al., 2017; Qian et al., 2017; Zhan et al., 2017; Qiao et al., 2018a, 2019; Ji et al., 2019; Sun et al., 2019; Wang et al., 2019; Xu et al., 2019; Santana-Rivera et al., 2020), or targeting with antibodies (Hsiao et al., 2013; Principe et al., 2015), microRNA (miR) (Liu et al., 2018), or long non-coding RNAs (lncRNAs) (Yu et al., 2018). This evidence concerns the gene ENO1 and cancer.