Gemta et al. (2019) recently reported that downregulation of ENO1 activity represses the glycolytic activity of tumor infiltrating CD8+ lymphocytes (CD8+ TILs), leading to their functional exhaustion. This impaired ENO1 function is unrelated to its expression, suggesting the involvement of post-transcriptional regulatory mechanisms such as PTMs influencing ENO1 enzymatic activity or subcellular localization (Gemta et al., 2019). The gene discussed is ENO1; the disease is neoplasm.