PLG and neoplasm: Acting as a plasminogen receptor, ENO1 “moonlights” on the surface of tumor cells to facilitate plasminogen conversion into plasmin (Miles et al., 1991; Redlitz et al., 1995; Capello et al., 2011; Diaz-Ramos et al., 2012; Ceruti et al., 2013; Hsiao et al., 2013; Didiasova et al., 2014, 2019).