ENO1 is also localized on the surface of cancer cells where it enhances plasmin formation (Miles et al., 1991; Redlitz et al., 1995) to promote extracellular matrix degradation, cell migration, invasion, and metastasis (Hsiao et al., 2013; Didiasova et al., 2014; Principe et al., 2015, 2017; Zakrzewicz et al., 2018). Here, PLG is linked to cancer.