BGN and neoplasm: Although no direct reports have confirmed that Bgn contribute to the remodeling of the tumor microenvironment and participate in EMT for tumorigenesis, various evidence of Bgn in multiple mouse disease models (Chen et al., 2000; Schaefer et al., 2004; Cheng et al., 2012; Sugg et al., 2014) have confirmed its different pathological significance.