CD4 and neoplasm: There were lower tumor purity (P = 4.75e-16) and higher percent of tumor-infiltrating immune cells (B cell P = 1.48e-05, T cell CD4 P = 8.26e-4, Neutrophil P = 3.58e-06, and macrophage P = 7.14e-10) in C1 than C2 (Figure 1A).