Forkhead box O (FOXO) transcription factors, including FOXO1 (FKHR), FOXO3a (FKHRL1), FOXO4 (AFX), and FOXO6, have also been increasingly recognized as tumor suppressors through serving as pivotal connection points to allow stress signals, proliferative nutrient and diverse to cluster and integrate with distinct gene networks to control cell fate, metabolism, and cancer development (Farhan et al., 2017; Jiramongkol and Lam, 2020). The gene discussed is FOXO1; the disease is cancer.