We identified 10 hub genes, DSE, IL17RD, DUSP18, ROBO3, BANK1, MRC2, LGALSL, TFPI, GAP43 and HYAL1, which updated our perspective on the pathogenesis of IDD, and could also serve as novel biomarkers and potential therapeutic targets. Here, GAP43 is linked to intervertebral disk degenerative disorder.