However, mice with an IL-1R1 deficiency on radioresistant lung epithelial cells fail to raise a TH2 immune response and do not develop house dust mite-induced asthma, whereas caspase 8-mediated IL-1 activity promotes TH2 immunity and contributes to the development of asthma pathogenesis (161, 162). This evidence concerns the gene CASP8 and asthma.