Data also support the potential of GSK3 inhibitors in promoting maturation and cytotoxicity of NK cells following expansion ex vivo with IL-15 (146) GSK3 inhibition increased NK cell production of TNF and IFN-γ as well as bolstered the NK cytotoxicity per se and via ADCC, which translated into better tumor control of human ovarian cancer in a mouse model. The gene discussed is TNF; the disease is neoplasm.