CD28 and autoimmune thrombocytopenic purpura: In addition, analysis using the dominant model showed that the CA/AA genotypes of TIM3 rs10515746 and CC/CT genotypes of CD28 rs1980422 significantly increased the ITP risk compared with homozygous major alleles (OR = 3.617, 95% CI = 1.170–11.185, p = 0.026 and OR = 1.645, 95% CI = 1.093–2.475, p = 0.017, respectively, Table 4).