As demonstrated in our previous studies (6, 21), adoptive transfer of Treg-of-B (P) cells could inhibit allergic asthmatic symptoms, including decreased amounts of OVA-specific IgE and IgG1, elevated OVA-specific IgG2a, reduced airway hyperresponsiveness, and infiltrated eosinophil in BALF, lower amounts of eotaxin in BALF and inflammation score in lung tissue (Figures 4B–E). The gene discussed is IGHE; the disease is airway hyperresponsiveness.