Pre-BCG tissues were enriched with genes related to bladder cancer progression, such as CRTAC1 (28), ERBB4 (29), KRT20 (28, 30), OTX-AS1 (31), SCNN1G (30); and ion transport related molecules, such as ANO1 (32), GRIK3 (33), which have been shown to associate with poor prognosis in other cancers (Figures 3B, C). The gene discussed is GRIK3; the disease is cancer.