CRTAC1 and cancer: Pre-BCG tissues were enriched with genes related to bladder cancer progression, such as CRTAC1 (28), ERBB4 (29), KRT20 (28, 30), OTX-AS1 (31), SCNN1G (30); and ion transport related molecules, such as ANO1 (32), GRIK3 (33), which have been shown to associate with poor prognosis in other cancers (Figures 3B, C).