Mechanistically, inhibition of PI3Kγ decreased TAM expression of genes associated with immune suppression and tumor angiogenesis (Arg1, Tgfb, Il1b, Il6, Vegfa), and upregulated expression of genes associated with anti-tumor immunity (Il12 and Ifng), suggesting TAM reprogramming (148). This evidence concerns the gene TGFB1 and neoplasm.