Moreover, STING protects mice from HSV-1 lethal infection via intravenous and intracerebral routes, while mucosal infection of HSV-1 in STING−/− mice results in the increased corneal and trigeminal ganglia viral titers, demonstrating the importance of STING in host defense against HSV-1 in vivo (53). The gene discussed is STING1; the disease is infection.