Stimulated by antigens, immature DCs migrate toward chemokine ligands CCL19 and CCL21 into lymph nodes and gradually develop into a mature state, highly expressing MHC I molecules, MHC II molecules, costimulatory molecules and adhesion molecules (25), then mature DCs active CD4+T cells and CD8+T cells at the tumor site migrate to lymphoid organs to build immune memory. Here, CD4 is linked to neoplasm.