In the same model of colitis, but in a different strain of genetically modified mice, the GILZ B cell-conditional knock-out mice (GILZ B cKO), 3 day-treatment with the recombinant TAT-GILZ protein reversed the symptoms of DNBS-induced colitis, similar to wild-type mice (80, 81). The gene discussed is TSC22D3; the disease is colitis.