HSP90B2P and neoplasm: Tumor antigens can be recognized and uptaken by the antigen-presenting cell (APC) as a complex with Hsps, identified as “Hsp-peptide complex,” which could be either internalized by CD91-mediated endocytosis or bound by Hsps receptors, such as SREC-I (Scavenger receptor expressed by endothelial cells) and LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) expressed on cell surface, resulting in APC activation (130).