DAMP by active secretion by immune cells or passive extracellular release by necrotic cellsBinding to TLR2, TLR4, and RAGE, associated or not to nucleosomes, LPS, DNA, and RNA and uptakeDimerization with CXCL12 and binding to CXCR4Activation and maturation by induction of tumor debris uptake and maturation. The gene discussed is CXCL12; the disease is neoplasm.