CFLAR and cancer: Therefore, it is unsurprising that high levels of c-FLIP has been reported in several cancer settings such as colorectal cancer (46), cervical cancer (47), pancreatic cancer (48), lung cancer (49), breast cancer (50), Burkitt’s lymphoma (51), and non-Hodgkin’s Lymphoma (52) as well as that patients with tumors expressing high levels of FLIP tend to have a poorer prognosis (53, 54).