In a mouse model of glioma, CD11b-expressing, brain-infiltrating leukocytes are the main source of type I IFNs and tumor-bearing mice knockout for STING showed lower expression of IFNs, an increased amount of immature myeloid suppressor and regulatory T cells, and a decrease of IFNγ-producing CD8+ T cells, associated to a poorer survival rate, compared to wild-type tumor-bearing mice (175). The gene discussed is IFNG; the disease is neoplasm.