The mechanism by which HSP90 modulates antigen presentation is not fully understood; however, in NOD mice, it has been shown that HSP90 is secreted extracellularly in exosomes (94), suggesting a receptor-mediated uptake of HSP90 immunogenic peptide fragments by APCs to induce T cell-mediated autoimmunity in T1D. This evidence concerns the gene HSP90AA1 and Autoimmunity.