INS and Autoimmunity: Oral administration of DiaPep277 increased IL-4 and IL-10 secretion and decreased IFN-γ secretion, meaning that it induced a Th2 response which reduced Th1 cell-induced autoimmunity to HSP60, GAD, and insulin; the T-cell response to bacterial antigen peptide treatment in DiaPep277 treated mice was, however, unaffected (58, 61).