Growth hormone release; Starvation, same as in calorie restriction in sepsis, causes to synthesize octonylated peptide ghrelin from proghrelin by Ghrelin O- acyltransferase (GOAT) which stimulates Growth hormone from pituitary cells to normalize blood glucose levels (10). Sepsis and prolonged illness can cause hyperglycemia. Given the impact of Ghrelin in controlling glucose homeostasis, the beneficial outcomes of Ghrelin treatment in sepsis could be mediated through maintaining normoglycemia in septic patients.Appetite stimulation;Anti-inflammation. The gene discussed is GHRL; the disease is Hyperglycemia.