There is a trend toward increased frequency of HLA-DQB1*05:02 in countries with lower latitude, such as Italy, which also show increased frequency of MuSK MG (92) and pemphigus (93), while there is a reduced frequency for HLA-DRB1*04 and no apparent change in HLA-DRB1*14 in countries with low latitudes. Here, HLA-DRB1 is linked to pemphigus.