PLA2R1 and membranous glomerulonephritis: Two risk alleles for membranous nephropathy with PLA2R antibodies were identified in a Han Chinese population in DRB1*15:01 and DRB1*03:01 (43), either of which were found in 73.6% of the patient cohort (compared to 33% in the healthy control population), and that contained specific amino acid variants in the peptide-binding groove of the HLA class II molecules which is responsible for antigen presentation to the T-cell receptor (43, 44).