3) Also IL-4 and IL-10 levels were increased in an adoptive transfer model of pemphigus vulgaris (126), and 4) IL-10 levels are elevated in serum of pemphigus patients (127, 128), serum of MuSK-MG patients (129) and serum of patients with thrombotic thrombocytopenic purpura (130), but in the latter study the IgG subclass levels were not entirely clear, with some patients also demonstrating high levels of complement fixing antibodies and complement C3a and C5a, suggesting that IgG4 was not the predominant subclass. The gene discussed is IL10; the disease is thrombotic thrombocytopenic purpura.