5) Interestingly, increased levels of IL-10 producing Bregs was associated with favorable response after B-cell depletion therapy with Rituximab in pemphigus (142), which may indicate a protective role for IL-10 and Bregs, but this could also have been an unrelated side-effect of Rituximab-induced increase in cytokines that stimulate IL-10 production (143, 144). The gene discussed is IL10; the disease is pemphigus.