IFN-γ is closely connected to the death of parotid epithelial cells in the salivary glands (70, 71) IFN-γ significantly recruits the chemokines CXCL9 and CXCL10 on the surface of submandibular epithelial cells, then immune cells home to lesions, and exacerbate the progression of SS (35, 86) (Figure 1). The gene discussed is CXCL10; the disease is synovial sarcoma.