IRF4 and colitis: Given the T cell-intrinsic role of IRF4 in driving Th17 cell differentiation in vitro (62) and also in the context of colitis in vivo (32), our data support the conclusion that inactivation of IRF4 universally protects against Th17 mediated colitis and suggest that strategies to interfere with IRF4 gene expression are of potential great interest to harness acute intestinal inflammation.