For other validated genes, although presenting major fold change differences, we could not provide feasible hypotheses for their potential role in TB protection or immune system functioning, as is the case of Cdo1 (Cysteine Dioxygenase Type 1, upregulated), F7 (Coagulation Factor VII, downregulated), Gmpr (Guanosine monophosphate reductase 1, downregulated) or Mlph (Melanophilin, downregulated). This evidence concerns the gene GMPR and tuberculosis.