BCR and tuberculosis: The main enriched pathways identified in the nanovaccine groups at 2 and 14 weeks in BAL were associated with many immune-related pathways such as cytokine signaling, TCR and BCR signaling or complement cascade. DAP12 signaling was also observed, involving DAP12-mediated activation signals in NK cells, granulocytes, monocytes/macrophages, and DCs (43, 44), although a published study associated activation of DAP12 in APCs with the delay in Th1 immunity in TB (45).