TNF and cirrhosis of liver: These data are in line with a former study displaying that TNF-α-induced activation of GSK3 (in contrast to IL-7 mediated GSK3-inhibition) results in endotoxin tolerance and survival in macrophages (15), as well as with a previous report that has identified a role of GSK3 in LPS-induced inflammation in patients with decompensated liver cirrhosis (25).