The main findings of the current study are: 1) significant increase in the circulating BMP2 in experimental models of type 1 and type 2 diabetes, 2) induction of both canonical and non-canonical pathways in HRECs by BMP2, 3) attenuation of BMP2-induced permeability by inhibitors of canonical or non-canonical pathways, 4) induction of oxidative stress in HRECs subjected to BMP2. This evidence concerns the gene BMP2 and type 2 diabetes mellitus.