PlGF promotes cardiac hypertrophy via endothelial cell release of NO which induces cardiomyocyte growth (350) and by inducing the secretion of paracrine factors (IL-6, IL-1b, Cxcl1) from endothelia and fibroblasts that promote cardiac adaptation and hypertrophy (351–353). The gene discussed is IL6; the disease is cardiac hypertrophy.