The description of the full spectrum of PlGF’s biological role is beyond the scope of this review but to mention a few, PlGF plays a role in inflammatory response (305, 306), promotes bone repair (307), sustains the proangiogenic M2 phenotype of tumor associated macrophages (308), affects dendritic cell differentiation and maturation (309), supports the generation of an inflammatory status driving adaptive cardiac remodeling (310). Here, PGF is linked to neoplasm.