Contrary to what was observed in the brain, the systemic lymphopenia in the K14-VEGFR3-Ig genotype corresponds to a relative frequency reduction in peripheral CD8+ T cells (TG naïve = 25.75 ± 3.61%; WT naïve = 42.70 ± 4.17% of T cells; ChiSq: 14.727, mean ranks: 5.00/15.50, p = 1e-04) (Figure 7B). The gene discussed is FLT4; the disease is lymphopenia.