NLRP3 and cryopyrin-associated periodic syndrome: Indeed, multiple NLRP3 gene mutations have been reported in various autoimmune inflammatory diseases, such as cryopyrin-associated periodic syndrome (CAPS), Crohn’s disease, psoriatic juvenile idiopathic arthritis, rheumatoid arthritis, food-induced anaphylaxis, aspirin-induced asthma, urticaria, type 2 DM, hypertension, and cancer.