IFNA1 and Cirrhosis: From these six clinically relevant RASs > 100X, five (M28T in 1 patient, Q30R in 2, Q30H in 1, and L31M in 1) were identified in patients with cirrhosis that had a previous history of treatment with IFN-based regimens, and one (M28T) was detected in a non-cirrhotic patient (P < 0.05).