IGF1R and cancer: Several key signaling proteins including Ras/MAPK (72–74) and RTKs, including MET, KIT, VGFR2, EGFR, FGFR (21, 75–77) and IGF-1R (22) have been demonstrated to locate to the Golgi apparatus, which acts as a signaling hub in normal and cancer cells (Figure 2A).