Transgenic expression of a genetically mutated, constitutively active form of the WNT signaling transducer β-catenin in embryonic pituitary progenitor cells (95) or in SOX2+ cells (7) results in the development of lesions in the gland showing characteristics of adamantinomatous craniopharyngoma (ACP), a benign but burdening tumor mostly occurring in children (96). The gene discussed is SOX2; the disease is neoplasm.