Endogenous Cushing`s syndrome (CS) is characterized by oversecretion of glucocorticoids due to adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma (in most cases of endogenous CS), ectopic ACTH production, or autonomous adrenal overproduction of cortisol (1). The gene discussed is POMC; the disease is pituitary gland adenoma.