Endogenous Cushing`s syndrome (CS) is characterized by oversecretion of glucocorticoids due to adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma (in most cases of endogenous CS), ectopic ACTH production, or autonomous adrenal overproduction of cortisol (1). This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.