This phenomenon has recently been observed in a trial of resmetirom, a highly selective thyroid hormone receptor β (THR-β) agonist [(40), NCT03900429] where it was observed that fat reduction, as measured by week 12 MRI-PDFF, predicted NASH resolution on biopsy in 64% of cases at week 36. The gene discussed is THRB; the disease is metabolic dysfunction-associated steatohepatitis.