CT-pro-ET-1 levels on day 1 were higher in patients suffering from severe strokes compared to moderate strokes, but this difference was not statistically significant (NIHSS ≤6: CT-pro-ET-1 on day 1 8.4 pg/ml, IQR 7.7–9.4, vs. NIHSS ≥7: 8.8 pg/ml, IQR 7.6–9.9, p = 0.16). This evidence concerns the gene EDN1 and stroke disorder.