AQP4 and acute disseminated encephalomyelitis: MOGAD are characterized by monophasic or relapsing optic neuritis (ON), myelitis, brainstem, and cerebral cortical encephalitis (1, 10, 11), and in children by monophasic acute disseminated encephalomyelitis (ADEM) and ADEM followed by recurrent ON, multiphasic disseminated encephalomyelitis or AQP4-ab-negative neuromyelitis optica spectrum disorders (NMOSD) (12, 13).