Neuromyelitis optica spectrum disorders (NMOSD), which include the neuromyelitis optica (NMO), previously known as Devic's syndrome, are defined as a group of inflammatory disorders of the central nervous system(CNS) characterized by episodes of immune-mediated demyelination and axonal damage preferentially affecting the optic nerves and spinal cord (1); these disorders are mainly associated with aquaporin-4 [AQP4–immunoglobulin G (IgG)] seropositivity. Here, AQP4 is linked to neuromyelitis optica.